Selected Publications

      https://orcid.org/0000-0002-1955-1975

• Wongpinyochit T, Vassileiou AD, Gupta S, Mushrif SH, Johnston BF, Seib FP (2019). Unraveling the impact of high-order silk structures on molecular drug binding and release behaviors. The Journal of Physical Chemisry Letters 10, 4278−4284. DOI: 10.1021/acs.jpclett.9b01591

• Totten JT, Wongpinyochit T, Carolla J, Duarte I, Seib FP (2019). PEGylation-dependent metabolic rewiring of macrophages with silk fibroin nanoparticles. ACS Applied Materials & Interfaces  11, 14515-14525. doi: 10.1021/acsami.8b18716
  

• Wahlich J, Desai A, Greco F, Hill K, Jones AT, Mrsny RJ, Pasut G, Perrie Y, Seib FP, Seymour LW, Uchegbu IF (2019). Nanomedicines for the Delivery of Biologics. Pharmaceutics  11,  pii: E210. DOI: 10.3390/pharmaceutics11050210.

• Gorenkova N, Osama I, Seib FP & Carswell HVO* (2019). In vivo evaluation of engineered self-assembling silk fibroin hydrogels after intracerebral injection in a rat stroke model. ACS Biomaterials Science & Engineering 5, 859–869, DOI: 10.1021/acsbiomaterials.8b01024. 

• Wongpinyochit T, Totten JT,  Johnston BF, Seib FP (2019) Microfluidic-assisted silk nanoparticle tuning. Nanoscale Advances 1, 873-883 doi:10.1039/C8NA00208H

• Holland C, Numata K, Rnjak-Kovacina J, Seib FP (2019). The biomedical use of silk: past, present, future. Advanced Healthcare Materials 8, e1800465 doi:10.1002/adhm.201800465

• Tran SH, Wilson CG, Seib FP (2018). A Review of the emerging role of silk for the treatment of the eye. Pharmaceutical Research  35, 248 doi:10.1007/s11095-018-2534-y

• Ibrahim O, Gorenkova N, McKittrick CM, Wongpinyochit T, Goudie A, Seib FP, Carswell HVO (2018). In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain application. Scientific Reports  8,13655. https://doi.org/10.1038/s41598-018-31905-5
  

• Brownlee WJ, Seib FP (2018). Impact of the hypoxic phenotype on the uptake and efflux of nanoparticles by human breast cancer cells. Scientific Reports 8, 12318. https://doi.org/10.1038/s41598-018-30517-3

• Newland B, Taplan C, Pette D, Friedrichs J, Steinhart M, Wang W, Voit B, Seib FP, Werner C (2018). Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery.  Nanoscale  10, 8413-8421 doi:10.1039/c8nr00603b.

• Seib FP (2018) Reverse-engineered silk hydrogels for cell and drug delivery. Therapeutic Delivery  9, 469-487. doi: 10.4155/tde-2018-0016.

• Wongpinyochit T, Johnston BF, Seib FP ( 2018)  Degradation behavior of silk nanoparticles – enzyme responsiveness.  ACS Biomaterials Science & Engineering 4,  942–95, 10.1021/acsbiomaterials.7b01021
  

• Totten JD, Wongpinyochit T, Seib FP (2017). Silk nanoparticles: proof of lysosomotropic anticancer drug delivery at single-cell resolution. Journal of Drug Targeting 25, 865–872 https://doi.org/10.1080/1061186X.2017.1363212 

  
  

• Maitz HF, Sperling C, Wongpinyochit T, Herklotz M, Werner C, Seib FP (2017). Biocompatibility assessment of silk nanoparticles: hemocompatibility and internalization by human blood cells. Nanomedicine: Nanotechnology, Biology and Medicine.  8, 2633-2642 https://doi.org/10.1016/j.nano.2017.07.01

• Saborano R, Wongpinyochit T, Totten JD, Johnston BF, Seib FP, Duarte IF (2017) Metabolic Reprogramming of Macrophages Exposed to Silk, Poly(lactic-co-glycolic acid) and Silica Nanoparticles. Advanced Healthcare Materials 6, 1601240, DOI:10.1002/adhm.201601240

• Seib FP (2017) Silk nanoparticles—an emerging anticancer nanomedicine. AIMS Bioengineering 4, 239-258. [DOI:10.3934/bioeng.2017.2.239] 

• Wongpinyochit T,  Johnston BF, Seib FP (2016) Manufacture and Drug Delivery Applications of Silk Nanoparticles. Journal of Visualized Experiments (116). e54669  [DOI: 10.3791/54669] 

• Seib FP, Tsurkan M, Freudenberg U, Kaplan DL, Werner C (2016) Heparin-Modified Polyethylene Glycol Microparticle Aggregates for Focal Cancer Chemotherapy. ACS Biomaterials Science & Engineering 2, 2287–2293  [DOI: 10.1021/acsbiomaterials.6b00495] 

• Wongpinyochit T ,  Uhlmann P,  Urquhart AJ ,  Seib FP (2015) PEGylated Silk Nanoparticles for Anticancer Drug Delivery. Biomacromolecules 16, 3712-3722  [DOI: 10.1021/acs.biomac.5b01003] 

• Seib FP, Coburn J, Konrad I, Klebanov N, Jones GT, Blackwood B, Charest A, Kaplan DL, Chiu B (2015) Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo. Acta Biomaterials 20, 32-38 [DOI: 10.1016/j.actbio.2015.04.003] 
  

• Seib FP, Berry JE, Shiozawa Y, Taichman RS, Kaplan DL (2015) Tissue engineering a surrogate niche for metastatic cancer cells. Biomaterials 51, 313-319 [DOI: 10.1016/j.biomaterials.2015.01.076.  

• Chiu B, Coburn J, Pilichowska M, Holcroft C, Seib FP, Charest A, Kaplan DL (2014) Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model. British Journal of Cancer 111, 708-715 [DOI: 10.1038/bjc.2014.324.]

• Seib FP, Herklotz M, Burke KA, Maitz MF, Werner C, Kaplan DL, (2014) Multifunctional silk-heparin biomaterials for vascular tissue engineering applications. Biomaterials 35, 83-91 [DOI: 10.1016/j.biomaterials.2013.09.053] 

• Vanterpool FA Cantini M Seib FP Salmeron-Sanchez M (2014) A material-based platform to modulate fibronectin activity and focal adhesion assembly. BioResearch Open Access 3, 286-96 [DOI: 10.1089/biores.2014.0033]

• Prewitz MC, Seib FP, von Bonin M, Friedrichs J, Stißel A, Niehage C, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C. (2013) Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nature Methods 10, 788 [DOI: 10.1038/nmeth.2523]

• Seib FP Kaplan DL (2013) Silk for drug delivery applications: opportunities and challenges. Israel Journal of Chemistry 53, 756-766 

• Chiu B, Coburn J, Seib, FP, Charest A and Kaplan DL (2013) Surgical resection combined with application of doxorubicin-loaded sustained release silk film as a treatment strategy in an orthotopic xenograft neuroblastoma mouse model. Journal of the American College of Surgeons 217, S3, S77

• Seib FP, Jones G, Rnjak-Kovacina J, Lin Y, Kaplan DL, (2013) pH-dependent anticancer drug release from silk nanoparticles. Advanced Healthcare Materials 2, 1606-1611 [DOI: 10.1002/adhm.201300034] 

• Seib FP, Pritchard EM, Kaplan DL (2013) Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer. Advanced Functional Materials 23, 58-65 [DOI: 10.1002/adfm.201201238] 

• Lescarbeau RM, Seib FP, Prewitz M, Werner C, Kaplan DL (2012) In vitro model of metastasis to bone marrow mediates prostate cancer castration resistant growth through paracrine and extracellular matrix factors. PLoS ONE 7, e40372 [DOI: 10.1371/journal.pone.0040372] 

• Prewitz M, Seib FP, Pompe T, Werner C (2012) Polymeric biomaterials for stem cell bioengineering. Macromolecular Rapid Communications 33, 1420-1431 [DOI: 10.1002/marc.201200382] 

• Reagan MR, Seib FP, McMillin DW, Sage EK, Mitsiades CS, Janes SM, Ghobrial IM, Kaplan DL. (2012) Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ. Journal of Breast Cancer 15, 273-82 [DOI: 10.4048/jbc.2012.15.3.273] 

• Seib FP, Kaplan DL (2012) Doxorubicin-loaded silk films: drug-silk interactions and in vivo performance in human orthotopic breast cancer. Biomaterials 33, 8442-50 [DOI: 10.1016/j.biomaterials] 

• Liebner F, Dunareanu R, Opietnik  M, Haimer E, Wendland M, Werner C, Maitz M, Seib P, Neouze MA, Potthast A, Rosenau T (2012) Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties Holzforschung 66, 317-332 [DOI: 10.1515/HF.2011.163] 

• Seib FP, Maitz MF, Hu X, Werner C, Kaplan DL (2012) Impact of processing parameters on the haemocompatibility of Bombyx mori silk films. Biomaterials 33, 1017-23 [DOI: 10.1016/j.biomaterials.2011.10.063] 

• Sobkow L, Seib FP, Prodanov L, Kurth I, Drichel J, Bornhäuser M, Werner C (2011) Prolonged transendothelial migration of human haematopoietic stem and progenitor cells (HSPCs) towards hydrogel-released SDF1. Annals of Hematology 90, 865-71 [DOI: 10.1007/s00277-011-1155-x] 

• Seib FP, Lanfer B, Bornhäuser M, Werner C. (2010) Biological activity of extracellular matrix-associated BMP-2. Journal of Tissue Engineering and Regenerative Medicine 4, 324-7 [DOI: doi: 10.1002/term.240] 

• Stiehler M, Seib FP, Rauh J, Goedecke A, Werner C, Bornhäuser M, Günther KP, Bernstein P (2010) Cancellous bone allograft seeded with human mesenchymal stromal cells: a potential good manufacturing practice-grade tool for the regeneration of bone defects. Cytotherapy 12, 658-68 

• Lanfer B, Seib FP, Freudenberg U, Stamov D, Bley T, Bornhäuser M, Werner C (2009) The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices. Biomaterials 30, 5950-8 [DOI: 10.1016/j.biomaterials.2009.07.039] 

• Seib FP, Franke M, Jing D, Werner C, Bornhäuser M (2009) Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells. European Journal of Cell Biology 88, 257-71 [DOI: doi: 10.1016/j.ejcb.2009.01.003] 

• Seib FP, Müller K, Franke M, Grimmer M, Bornhäuser M, Werner C (2009) Engineered extracellular matrices modulate the expression profile and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells. Tissue Engineering Part A 15, 3161-71 [DOI: doi: 10.1089/ten.TEA.2008.0600] 

• Prewitz M, Seib FP, Bornhäuser M and Werner C (2009) Engineering Biomimetic Culture Systems: Impact On Human Bone Marrow-Derived Stem Cells. Blood 114, (issue 22) 1401-1402

• Seib FP, Prewitz M, Werner C, Bornhäuser M (2009) Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs). Biochemical and Biophysical Research Communications 389, 663-7 [DOI: doi: 10.1016/j.bbrc.2009.09.051] 

• Liebner F,  Potthast A, Rosenau T,  Haimer E, Loidl, D, Tschegg S,  Neouze MA, Maitz M, Seib P, Werner C  (2009) Ultra lightweight cellulosic aerogels: Preparation and properties. (Meeting abstract).  American Chemical Society  237, 141-CELL

• Alberti K, Davey RE, Onishi K, George S, Salchert K, Seib FP, Bornhäuser M, Pompe T, Nagy A, Werner C, Zandstra PW (2008) Functional immobilization of signaling proteins enables control of stem cell fate. Nature Methods 5, 645-50 [DOI: 10.1038/nmeth.1222] 

• Seib FP, Jones AT, Duncan R (2007) Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells. Journal of Controlled Release 117, 291-300 

• Seib FP, Jones AT, Duncan R (2006) Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation B16F10 cells and use to study the intracellular fate of HPMA copolymer - doxorubicin. Journal of Drug Targeting 14, 375-90